RapamycinFungusV1, Main, Exploration, bibRecord, 000896

Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses.

Identifieur interne : 000896 ( Main/Exploration ); précédent : 000895; suivant : 000897

Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses.

Auteurs : Barbara Kroczynska [États-Unis] ; Gavin T. Blyth ; Robert L. Rafidi ; Beata Majchrzak-Kita [Canada] ; Lucy Xu ; Diana Saleiro ; Ewa M. Kosciuczuk [États-Unis] ; Jacek Jemielity [Pologne] ; Bing Su [République populaire de Chine] ; Jessica K. Altman [États-Unis] ; Elizabeth A. Eklund [États-Unis] ; Eleanor N. Fish [Canada] ; Leonidas C. Platanias [États-Unis]

Source :

The Journal of biological chemistry [ 1083-351X ] ; 2017.

RBID : pubmed:28174303

Descripteurs français

English descriptors

KwdEn :
- Adaptor Proteins, Signal Transducing (immunology), Animals (MeSH), Carrier Proteins (immunology), Cell Line (MeSH), Humans (MeSH), Immunity, Innate (MeSH), Interferon-gamma (immunology), Mice (MeSH), Phosphorylation (MeSH), Proto-Oncogene Proteins c-akt (chemistry), Proto-Oncogene Proteins c-akt (immunology), STAT1 Transcription Factor (chemistry), STAT1 Transcription Factor (immunology), Signal Transduction (MeSH).
MESH :
- chemical , chemistry : Proto-Oncogene Proteins c-akt, STAT1 Transcription Factor.
- chemical , immunology : Adaptor Proteins, Signal Transducing, Carrier Proteins, Interferon-gamma, Proto-Oncogene Proteins c-akt, STAT1 Transcription Factor.
- Animals, Cell Line, Humans, Immunity, Innate, Mice, Phosphorylation, Signal Transduction.

Abstract

The precise signaling mechanisms by which type II IFN receptors control expression of unique genes to induce biological responses remain to be established. We provide evidence that Sin1, a known element of the mammalian target of rapamycin complex 2 (mTORC2), is required for IFNγ-induced phosphorylation and activation of AKT and that such activation mediates downstream regulation of mTORC1 and its effectors. These events play important roles in the assembly of the eukaryotic translation initiation factor 4F (eIF4F) and mRNA translation of IFN-stimulated genes. Interestingly, IFNγ-induced tyrosine phosphorylation of STAT1 is reduced in cells with targeted disruption of Sin1, leading to decreased transcription of several IFNγ-inducible genes in an mTORC2-independent manner. Additionally, our studies establish that Sin1 is essential for generation of type II IFN-dependent antiviral effects and antiproliferative responses in normal and malignant hematopoiesis. Together, our findings establish an important role for Sin1 in both transcription and translation of IFN-stimulated genes and type II IFN-mediated biological responses, involving both mTORC2-dependent and -independent functions.

DOI: 10.1074/jbc.M116.757666
PubMed: 28174303
PubMed Central: PMC5377787

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000880
to stream Main, to step Curation: 000880

Le document en format XML

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<author><name sortKey="Kroczynska, Barbara" sort="Kroczynska, Barbara" uniqKey="Kroczynska B" first="Barbara" last="Kroczynska">Barbara Kroczynska</name>
<affiliation><nlm:affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>the Department of Radiation Oncology, Northwestern University, Chicago, Illinois 60611.</nlm:affiliation>
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<placeName><region type="state">Illinois</region>
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<wicri:noCountry code="subField">and</wicri:noCountry>
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<wicri:noCountry code="subField">and</wicri:noCountry>
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<author><name sortKey="Majchrzak Kita, Beata" sort="Majchrzak Kita, Beata" uniqKey="Majchrzak Kita B" first="Beata" last="Majchrzak-Kita">Beata Majchrzak-Kita</name>
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<author><name sortKey="Xu, Lucy" sort="Xu, Lucy" uniqKey="Xu L" first="Lucy" last="Xu">Lucy Xu</name>
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<wicri:noCountry code="subField">and</wicri:noCountry>
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<author><name sortKey="Kosciuczuk, Ewa M" sort="Kosciuczuk, Ewa M" uniqKey="Kosciuczuk E" first="Ewa M" last="Kosciuczuk">Ewa M. Kosciuczuk</name>
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<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
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<author><name sortKey="Su, Bing" sort="Su, Bing" uniqKey="Su B" first="Bing" last="Su">Bing Su</name>
<affiliation><nlm:affiliation>the Department of Immunobiology and the Vascular Biology and Therapeutics Program, Yale University, New Haven, Connecticut 06520, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>the Shanghai Institute of Immunology and Department of Microbiology and Immunology, Shanghai JiaoTong University School of Medicine, Shanghai 200000, China.</nlm:affiliation>
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<wicri:regionArea>the Shanghai Institute of Immunology and Department of Microbiology and Immunology, Shanghai JiaoTong University School of Medicine, Shanghai 200000</wicri:regionArea>
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<author><name sortKey="Altman, Jessica K" sort="Altman, Jessica K" uniqKey="Altman J" first="Jessica K" last="Altman">Jessica K. Altman</name>
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<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612.</nlm:affiliation>
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<author><name sortKey="Eklund, Elizabeth A" sort="Eklund, Elizabeth A" uniqKey="Eklund E" first="Elizabeth A" last="Eklund">Elizabeth A. Eklund</name>
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<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago</wicri:cityArea>
</affiliation>
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<author><name sortKey="Fish, Eleanor N" sort="Fish, Eleanor N" uniqKey="Fish E" first="Eleanor N" last="Fish">Eleanor N. Fish</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>the Toronto General Research Institute, University Health Network, and Department of Immunology, University of Toronto, Toronto, Ontario M5G 2M1</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Platanias, Leonidas C" sort="Platanias, Leonidas C" uniqKey="Platanias L" first="Leonidas C" last="Platanias">Leonidas C. Platanias</name>
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<country wicri:rule="url">États-Unis</country>
<wicri:regionArea>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine</wicri:regionArea>
<wicri:noRegion>Feinberg School of Medicine</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago</wicri:cityArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses.</title>
<author><name sortKey="Kroczynska, Barbara" sort="Kroczynska, Barbara" uniqKey="Kroczynska B" first="Barbara" last="Kroczynska">Barbara Kroczynska</name>
<affiliation><nlm:affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>the Department of Radiation Oncology, Northwestern University, Chicago, Illinois 60611.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>the Department of Radiation Oncology, Northwestern University, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Blyth, Gavin T" sort="Blyth, Gavin T" uniqKey="Blyth G" first="Gavin T" last="Blyth">Gavin T. Blyth</name>
<affiliation><nlm:affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rafidi, Robert L" sort="Rafidi, Robert L" uniqKey="Rafidi R" first="Robert L" last="Rafidi">Robert L. Rafidi</name>
<affiliation><nlm:affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Majchrzak Kita, Beata" sort="Majchrzak Kita, Beata" uniqKey="Majchrzak Kita B" first="Beata" last="Majchrzak-Kita">Beata Majchrzak-Kita</name>
<affiliation wicri:level="1"><nlm:affiliation>the Toronto General Research Institute, University Health Network, and Department of Immunology, University of Toronto, Toronto, Ontario M5G 2M1, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>the Toronto General Research Institute, University Health Network, and Department of Immunology, University of Toronto, Toronto, Ontario M5G 2M1</wicri:regionArea>
<wicri:noRegion>Ontario M5G 2M1</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Lucy" sort="Xu, Lucy" uniqKey="Xu L" first="Lucy" last="Xu">Lucy Xu</name>
<affiliation><nlm:affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Saleiro, Diana" sort="Saleiro, Diana" uniqKey="Saleiro D" first="Diana" last="Saleiro">Diana Saleiro</name>
<affiliation><nlm:affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kosciuczuk, Ewa M" sort="Kosciuczuk, Ewa M" uniqKey="Kosciuczuk E" first="Ewa M" last="Kosciuczuk">Ewa M. Kosciuczuk</name>
<affiliation><nlm:affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jemielity, Jacek" sort="Jemielity, Jacek" uniqKey="Jemielity J" first="Jacek" last="Jemielity">Jacek Jemielity</name>
<affiliation wicri:level="1"><nlm:affiliation>the Centre of New Technologies, University of Warsaw, 02-097 Warsaw, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>the Centre of New Technologies, University of Warsaw, 02-097 Warsaw</wicri:regionArea>
<wicri:noRegion>02-097 Warsaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Su, Bing" sort="Su, Bing" uniqKey="Su B" first="Bing" last="Su">Bing Su</name>
<affiliation><nlm:affiliation>the Department of Immunobiology and the Vascular Biology and Therapeutics Program, Yale University, New Haven, Connecticut 06520, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>the Shanghai Institute of Immunology and Department of Microbiology and Immunology, Shanghai JiaoTong University School of Medicine, Shanghai 200000, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>the Shanghai Institute of Immunology and Department of Microbiology and Immunology, Shanghai JiaoTong University School of Medicine, Shanghai 200000</wicri:regionArea>
<wicri:noRegion>Shanghai 200000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Altman, Jessica K" sort="Altman, Jessica K" uniqKey="Altman J" first="Jessica K" last="Altman">Jessica K. Altman</name>
<affiliation><nlm:affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Eklund, Elizabeth A" sort="Eklund, Elizabeth A" uniqKey="Eklund E" first="Elizabeth A" last="Eklund">Elizabeth A. Eklund</name>
<affiliation><nlm:affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fish, Eleanor N" sort="Fish, Eleanor N" uniqKey="Fish E" first="Eleanor N" last="Fish">Eleanor N. Fish</name>
<affiliation wicri:level="1"><nlm:affiliation>the Toronto General Research Institute, University Health Network, and Department of Immunology, University of Toronto, Toronto, Ontario M5G 2M1, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>the Toronto General Research Institute, University Health Network, and Department of Immunology, University of Toronto, Toronto, Ontario M5G 2M1</wicri:regionArea>
<wicri:noRegion>Ontario M5G 2M1</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Platanias, Leonidas C" sort="Platanias, Leonidas C" uniqKey="Platanias L" first="Leonidas C" last="Platanias">Leonidas C. Platanias</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and l-platanias@northwestern.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
<wicri:regionArea>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine</wicri:regionArea>
<wicri:noRegion>Feinberg School of Medicine</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago</wicri:cityArea>
</affiliation>
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<series><title level="j">The Journal of biological chemistry</title>
<idno type="eISSN">1083-351X</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptor Proteins, Signal Transducing (immunology)</term>
<term>Animals (MeSH)</term>
<term>Carrier Proteins (immunology)</term>
<term>Cell Line (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunity, Innate (MeSH)</term>
<term>Interferon-gamma (immunology)</term>
<term>Mice (MeSH)</term>
<term>Phosphorylation (MeSH)</term>
<term>Proto-Oncogene Proteins c-akt (chemistry)</term>
<term>Proto-Oncogene Proteins c-akt (immunology)</term>
<term>STAT1 Transcription Factor (chemistry)</term>
<term>STAT1 Transcription Factor (immunology)</term>
<term>Signal Transduction (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Facteur de transcription STAT-1 (composition chimique)</term>
<term>Facteur de transcription STAT-1 (immunologie)</term>
<term>Humains (MeSH)</term>
<term>Immunité innée (MeSH)</term>
<term>Interféron gamma (immunologie)</term>
<term>Lignée cellulaire (MeSH)</term>
<term>Phosphorylation (MeSH)</term>
<term>Protéines adaptatrices de la transduction du signal (immunologie)</term>
<term>Protéines de transport (immunologie)</term>
<term>Protéines proto-oncogènes c-akt (composition chimique)</term>
<term>Protéines proto-oncogènes c-akt (immunologie)</term>
<term>Souris (MeSH)</term>
<term>Transduction du signal (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Proto-Oncogene Proteins c-akt</term>
<term>STAT1 Transcription Factor</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term>
<term>Carrier Proteins</term>
<term>Interferon-gamma</term>
<term>Proto-Oncogene Proteins c-akt</term>
<term>STAT1 Transcription Factor</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Facteur de transcription STAT-1</term>
<term>Protéines proto-oncogènes c-akt</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Facteur de transcription STAT-1</term>
<term>Interféron gamma</term>
<term>Protéines adaptatrices de la transduction du signal</term>
<term>Protéines de transport</term>
<term>Protéines proto-oncogènes c-akt</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Humans</term>
<term>Immunity, Innate</term>
<term>Mice</term>
<term>Phosphorylation</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Humains</term>
<term>Immunité innée</term>
<term>Lignée cellulaire</term>
<term>Phosphorylation</term>
<term>Souris</term>
<term>Transduction du signal</term>
</keywords>
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<front><div type="abstract" xml:lang="en">The precise signaling mechanisms by which type II IFN receptors control expression of unique genes to induce biological responses remain to be established. We provide evidence that Sin1, a known element of the mammalian target of rapamycin complex 2 (mTORC2), is required for IFNγ-induced phosphorylation and activation of AKT and that such activation mediates downstream regulation of mTORC1 and its effectors. These events play important roles in the assembly of the eukaryotic translation initiation factor 4F (eIF4F) and mRNA translation of IFN-stimulated genes. Interestingly, IFNγ-induced tyrosine phosphorylation of STAT1 is reduced in cells with targeted disruption of Sin1, leading to decreased transcription of several IFNγ-inducible genes in an mTORC2-independent manner. Additionally, our studies establish that Sin1 is essential for generation of type II IFN-dependent antiviral effects and antiproliferative responses in normal and malignant hematopoiesis. Together, our findings establish an important role for Sin1 in both transcription and translation of IFN-stimulated genes and type II IFN-mediated biological responses, involving both mTORC2-dependent and -independent functions.</div>
</front>
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<DateCompleted><Year>2017</Year>
<Month>06</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1083-351X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>292</Volume>
<Issue>11</Issue>
<PubDate><Year>2017</Year>
<Month>03</Month>
<Day>17</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of biological chemistry</Title>
<ISOAbbreviation>J Biol Chem</ISOAbbreviation>
</Journal>
<ArticleTitle>Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses.</ArticleTitle>
<Pagination><MedlinePgn>4743-4752</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1074/jbc.M116.757666</ELocationID>
<Abstract><AbstractText>The precise signaling mechanisms by which type II IFN receptors control expression of unique genes to induce biological responses remain to be established. We provide evidence that Sin1, a known element of the mammalian target of rapamycin complex 2 (mTORC2), is required for IFNγ-induced phosphorylation and activation of AKT and that such activation mediates downstream regulation of mTORC1 and its effectors. These events play important roles in the assembly of the eukaryotic translation initiation factor 4F (eIF4F) and mRNA translation of IFN-stimulated genes. Interestingly, IFNγ-induced tyrosine phosphorylation of STAT1 is reduced in cells with targeted disruption of Sin1, leading to decreased transcription of several IFNγ-inducible genes in an mTORC2-independent manner. Additionally, our studies establish that Sin1 is essential for generation of type II IFN-dependent antiviral effects and antiproliferative responses in normal and malignant hematopoiesis. Together, our findings establish an important role for Sin1 in both transcription and translation of IFN-stimulated genes and type II IFN-mediated biological responses, involving both mTORC2-dependent and -independent functions.</AbstractText>
<CopyrightInformation>© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kroczynska</LastName>
<ForeName>Barbara</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>the Department of Radiation Oncology, Northwestern University, Chicago, Illinois 60611.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blyth</LastName>
<ForeName>Gavin T</ForeName>
<Initials>GT</Initials>
<AffiliationInfo><Affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rafidi</LastName>
<ForeName>Robert L</ForeName>
<Initials>RL</Initials>
<AffiliationInfo><Affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Majchrzak-Kita</LastName>
<ForeName>Beata</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>the Toronto General Research Institute, University Health Network, and Department of Immunology, University of Toronto, Toronto, Ontario M5G 2M1, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Lucy</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Saleiro</LastName>
<ForeName>Diana</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kosciuczuk</LastName>
<ForeName>Ewa M</ForeName>
<Initials>EM</Initials>
<AffiliationInfo><Affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jemielity</LastName>
<ForeName>Jacek</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>the Centre of New Technologies, University of Warsaw, 02-097 Warsaw, Poland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Su</LastName>
<ForeName>Bing</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>the Department of Immunobiology and the Vascular Biology and Therapeutics Program, Yale University, New Haven, Connecticut 06520, and.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>the Shanghai Institute of Immunology and Department of Microbiology and Immunology, Shanghai JiaoTong University School of Medicine, Shanghai 200000, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Altman</LastName>
<ForeName>Jessica K</ForeName>
<Initials>JK</Initials>
<AffiliationInfo><Affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eklund</LastName>
<ForeName>Elizabeth A</ForeName>
<Initials>EA</Initials>
<AffiliationInfo><Affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fish</LastName>
<ForeName>Eleanor N</ForeName>
<Initials>EN</Initials>
<AffiliationInfo><Affiliation>the Toronto General Research Institute, University Health Network, and Department of Immunology, University of Toronto, Toronto, Ontario M5G 2M1, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Platanias</LastName>
<ForeName>Leonidas C</ForeName>
<Initials>LC</Initials>
<AffiliationInfo><Affiliation>From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Feinberg School of Medicine, and l-platanias@northwestern.edu.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>the Division of Hematology-Oncology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 CA121192</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 CA077816</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>I01 CX000916</GrantID>
<Acronym>CX</Acronym>
<Agency>CSRD VA</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 CA161796</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 CA155566</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P30 CA060553</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>T32 CA080621</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>02</Month>
<Day>07</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Biol Chem</MedlineTA>
<NlmUniqueID>2985121R</NlmUniqueID>
<ISSNLinking>0021-9258</ISSNLinking>
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<NameOfSubstance UI="D048868">Adaptor Proteins, Signal Transducing</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
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<NameOfSubstance UI="C561937">stress-activated protein kinase-interacting protein, mouse</NameOfSubstance>
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<Chemical><RegistryNumber>82115-62-6</RegistryNumber>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D048868" MajorTopicYN="N">Adaptor Proteins, Signal Transducing</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D002352" MajorTopicYN="N">Carrier Proteins</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007113" MajorTopicYN="N">Immunity, Innate</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007371" MajorTopicYN="N">Interferon-gamma</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051057" MajorTopicYN="N">Proto-Oncogene Proteins c-akt</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050794" MajorTopicYN="N">STAT1 Transcription Factor</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">RNA editing</Keyword>
<Keyword MajorTopicYN="Y">antiviral agent</Keyword>
<Keyword MajorTopicYN="Y">innate immunity</Keyword>
<Keyword MajorTopicYN="Y">interferon</Keyword>
<Keyword MajorTopicYN="Y">signal transduction</Keyword>
<Keyword MajorTopicYN="Y">translation control</Keyword>
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	Serveur d'exploration sur la rapamycine et les champignons
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Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses.

Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses.

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